MAN Clout Ingredients & Servings:
Supplement Facts:
Serving Size: 1 Scoop (10.5g)
Servings Per Container: 50
Amount Per Serving:
Orotine? (Tricreatine Orotate): 3,000 mg
N-Acetyl-Cysteine: 2,000 mg
Beta-Alanine: 1,600 mg
Mag-Malate? (Magnesium Malate): 560.5 mg
Orotic Acid: 500mg
Vinpocetine: 8mg
Phospha-Drive?:
-Magnesium Phosphate, Dibasic: 351.5 mg
-Potassium Phosphate, Dibasic: 220 mg
-Sodium Phosphate, Monobasic: 216 mg
Other ingredients:
Natural and Artificial flavors, Maltodextrin, Citric acid, sucralose, Red#40, Acesulfame Potassium.
Directions: To optimize uptake and absorption of Clout? take one serving twice daily, one immediately preworkout and one with food separated by at least a 4-5 hour period. Following this routine for 28 days will optimize concentrations of the ingredients in Clout? in muscle tissues. Noticeable effects should be experienced within the first 3 days of use with 80% of total effectiveness achievable by day 12-14 and total effects at 28 days and longer. Clout? can be combined with BodyOctane? and Scorch?.
Lat's Break It Down To The Very Last Compound!
Find out exactly what the 7 never before combined Bioactives in Clout? are and what they do:
Bioactives # 1 & 2 Orotine? (TriCreatine-Orotate) & Orotic Acid
What Is It?
Orotine? (Tricreatine orotate) complex is an "exclusive" triple creatine molecule attached chemically to Orotic Acid. In Clout? its inclusion is at a dose to deliver the exact dose of creatine proven to enhance muscle creatine stores. Orotic Acid (OA) is bond to creatine and also supplied to exactly match orotic acid doses in human studies shown to enhance performance[10]. So why do creatine and OA work so well together? And how do they work in synergy?
How Does It Work?
Declining muscle pH can detrimentally affect muscle function and one possible way to prevent this decline is by enhancing the systems that prevent this fall. Think FIRE-EXTINGUISHER. Two central components of these systems are phosphocreatine and carnosine. True to form Clout? yet again delivers the exact dose of creatine shown to elevate muscle phosphocreatine levels.
Clout? also provides the exact level of Orotic Acid shown to work effectively on two levels:
1. Enhancement of performance. This may have been achieved by a selection of Mechanisms but of most importance is as a precursor for carnosine synthesis. In fact research proves that Orotic Acid is very much a nutrient that can increase muscle carnosine levels[11].
2. Orotic Acid has been shown to increase muscle Uridine levels. Work by Rosenfeldt et al. (1998) showed under hypoxic (lack of oxygen) conditions (found following anaerobic exercise) elevation of intramuscular Uridine levels increased muscle phosphocreatine and creatine levels 38% and 3%, respectively[12].
Elevated Uridine levels, a RNA base, has been shown to increase muscle contractile capacity.
That's Not All...Orotic Acid Has Been Proven To:
1. Enhance and Maintain ATP pools
2. Increase Glucose Uptake
3. Increase Ribose Moieties (R-1-P & R-5-P) Leading to Enhanced Ribose Formation
4. Increased Muscle Carnosine Stores
5. Support and Enhance Muscle Hypertrophy (via RNA synthesis support during growth)
What Evidence For Performance Effect?
Golf et al. (1998) carried out a human trial using again the exact dose delivered with Clout?[10]. The aim of this study was to assess the effects of Magnesium-Orotate on swim, cycling and run performance. Performance was enhanced with supplementation but backing up the influence of orotate rather than magnesium was the measured lower hydrogen ion levels. This is suggestive of enhanced buffering capacity via orotate by elevated muscle carnosine contents.
Therefore, these two ingredients may set off each others functions in many ways. Orotic Acid and creatine both enhance your muscles buffering capacity, literally putting out the fire. As an added bonus orotic acid may help preserve creatine levels during intense hypoxic (lacking oxygen) exercise[12].
Bioactive #3 Beta-Alanine
What Is It?
Beta-alanine is the direct precursor and to date the most effective enhancer of carnosine. This exciting nutrient is making a major impact in the sports nutrition arena thanks to BodyOctane? and has been proven to be effective in humans for enhancing muscle performance[13]. As previously mentioned, Clout? has placed in the exact amounts of each ingredient proven by research to enhance performance and the content of Beta-alanine is no different.
How Does It Work?
Beta-Alanine works by enhancing the buffering capacity in our muscle. It does this by elevating carnosine stores a highly effective cellular pH buffer[13, 14]... In fact the most effective cellular pH buffer.
What Evidence For Performance Effect?
In 2003 Harris et al.[13] investigated Beta-alanine supplementation and its influence on the capacity to undertake intense exercise normally associated with lactate accumulation [13]. The dose of beta-alanine delivered in Clout? enhanced maximal workout puts over a 4 minute maximal exercise test. Again authors suggested these beneficial performance effects down to increased muscle buffering capacity which aids the maintenance of muscle pH.
Bioactive #4 N-Acetyl Cysteine (NAC)
What Is It?
Acetyl group donation as mentioned earlier a donor of acetyl groups could radically impact performance by activating the PDH complex. One such acetyl donating nutrient is the antioxidant N-Acetyl cysteine. However, the great effects of NAC don't stop at delivering acetyl groups.
How Does It Work?
N-Acetyl Cysteine again is a powerful antioxidant and its main influence on muscle damaging free radicals is its influence at enhancing muscle and other cell glutathione levels[15]. Secondly, it can also provide acetyl groups which could be used for entry into the Krebs cycle and energy generation overcoming deficiencies in the PDH complex.
What Evidence For Performance Effect?
There are two immense supplementation studies that show the influence of cysteine donors on performance. Sen et al. (1994) gave 200 x 4mg/day of NAC and an 800mg bolus before a maximal bike test[16]. Clout? delivers probably the highest amounts of NAC in any sports supplement many times above the cysteine and acetyl groups delivered in these studies! OK back to the outcome of the Sen study, NAC resulted in a higher net post exercise antioxidant capacity[16]. But can elevating oxidative capacity through cysteine donation influence performance? The answer is simply YES! A study presented at the ACSM on whey protein delivering similar cysteine levels to those in Clout? improved muscle fatigue during fatiguing leg extension exercise[17].
Bioactive #5 Phospha-Drive?
What Is It?
Phosphate maybe one of, if not the most important mineral constituent required for cellular activity due to its biological interactions with metabolic intermediates and energy producing compounds. Changes in cellular phosphate levels have been linked to enhanced exercise capacity time and time again. Supplementation is a proven method to achieve this guaranteed performance effect.
How Does It Work?
There are many possible Mechanisms proposed for the proven influence of phosphate including:
1. Phosphate-stimulated glycolysis (enhanced energy production capacity)[18]
2. Increased red blood cell 2,3-DPG levels (Enhancing oxygen delivery to working muscles)[19]
3. Enhanced creatine phosphate synthesis (increased creatine stores)[20].
Therefore, it is easy to see how phosphate addition can further extend the influence of Clout? as the ultimate creatine and performance enhancer.
What Evidence For Performance Effect?
There are many studies proving the fantastic influence of this compound so let's take a look. Kreider et al. (1992) assessed the influence of 1000mg of phosphate 4 times a day for 3 days or a maltodextrine placebo. The results backed many other studies and showed that phosphate loading could enhance maximal exercise performance (40km time trial). The slightly lower dose of phosphate in Clout? compared to the study above were chosen because of not only the gastrointestinal stress caused by high dose phosphate but also because the creatine and phosphate combination included in Clout? should enhance muscle phosphate to equal and possibly greater levels than phosphates alone. (Check out our how to use guide at the end of this article).
Bioactive #6 Vinpocetine
What Is It?
Vinpocetine is an extract from lesser periwinkle plant (Vinca Minor). Because we know exercise performance is related to our ability to generate ATP and deliver oxygen the possible enhancing influence of Vinpocetine on these energy-generating systems made its inclusion in Clout? essential!
How Does It Work?
Vinpocetine has been shown to be effective by increasing 2,3 DPG levels (Oxygen delivery capacity)[23], ATP (energy levels)[24], and antioxidant activity[25].
What Evidence For Performance Effect?
The effects on exercise performance of Vinpocetine at this point do not exist. What dose exist are the effects in human studies looking at enhancing chemicals that we know can elevate performance capacity. In a study by Tohgi et al. subjects were given 15mg of Vinpocetine per day (a dose lower than that contained in Clout?) for 3 weeks[24]. By the end of the supplementation period there were huge increases in cellular ATP as well as an increase in 2,3 DPG[24].
Bioactive #7 Magnesium-Malate
What Is It?
Magnesium-Malate is the final nutrient that pushes the performance enhancing potential of Clout? through the roof! As we described at the beginning of this article magnesium is inextricably linked to countless cellular functions. As such the importance of magnesium as a performance enhance cannot be denied. Magnesium-Malate supplies extra malic acid, which has been shown to recycle pyruvate and lactate and help to fuel the kreb cycle (our natural energy producing cycle)[29].
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