Orotine from MAN:

They said it couldn?t be done, however the inventive minds at MAN Sports? believe that with imagination and knowledge greatness is realized. With the perfected infusion of knowledge and imagination, the greatest performance enhancing supplement of all time, just got better. That?s right, The KING of CREATINES? has arrived.

INTRODUCING OROTINE?

OROTINE? contains the patented CreaTate? Tricreatine Orotate (creatine + orotic acid) complex; an exclusive Creatine and Orotic Acid infusion. Remember Orotic Acid!

A genuine revolutionary breakthrough, creatine has been scientifically proven effective in maintaining ATP levels and increasing recovery during and following high intensity exercise. It is also a proven cell-volumizer, what is unknown to many of creatine is that it functions similar in fashion to carnosine in that it helps with the maintenance of cellular pH. Maintaining proper cell pH enhances performance! More evidence suggests creatine can reduce muscle damage from endurance exercise making it a great supplement for endurance and power athletes alike.

ENTER OROTIC ACID!

Orotic Acid (OA) is a precursor of pyrimidine and nucleic acids which are vital for optimal cell functioning and energy metabolism. OA enhances and maintains ATP pools in three ways:

1. The production of ribose moieties (R-1-P and R-5-P) for the salvage or de novo synthesis of purine nucleotides by a process know as "ribose transfer". Many of you may remember ribose (a sugar component of ATP) supplementation being touted as an enhancer of high intensity repetitive exercise performance. For a quick recap on the energy producing pathways of ribose seen.

The way OA enhances the formation of ATP is by providing the direct precursor to phosphoribosylpyrophosphate (PRPP) a key energy-supplying compound in the de-novo synthesis of purine and pyrimidine nucleotides (I know that's a real mouthful). The reserve of PRPP is poor because of the low capacity of the pentose phosphate pathway. Therefore the generation of ribose-5-phosphate (R-5-P) the immediate precursor to PRPP ribose supply can be enhanced with OA and as a result greater ATP regeneration.

2. The second pathway is by increasing the pool of Uridine Monophosphate (UMP), which requires ATP to convert to further downstream pyrimidine nucleotides (UTP & CTP). By increasing the levels of these nucleotides the draw on ATP reserves to synthesize them is decreased thereby enhancing the availability of ATP for other metabolic process such as energy and contractile producing pathways.

3. The final pathway is by means of elevation of intracellular glycogen stores. These elevated glycogen stores generated from a greater uptake of glucose lead to an enhanced capacity for ATP resynthesis from anaerobic glycolysis.

What this means is more energy for hard working muscles. Evidence also suggests OA can be used to synthesize carnosine (the ultimate buffering nutrient) by elevating its natural precursor ?beta-alanine?. This is illustrated in the chart below:

More recent studies have shown OA supplementation enhances endurance performance and exercise capacity. OA also has been shown to augment muscle hypertrophy and to increase the contractile capacity of muscle.

This new Creatine/Orotic Acid complex (OROTINE?) aka The KING of CREATINES! ? pushes the power to fight muscle fatigue to completely new levels. Not only do you get the scientifically proven power, endurance and recovery of creatine supplementation, but you also get the high energy, power, recovery and growth stimulating properties of Orotic Acid.


WHY OROTINE OVER OTHER FORMS OF CREATINE?

Contains 2 scientifically proven performance enhancing ingredients in one compound; Creatine and Orotic Acid!

Higher energy complex providing greater endurance and contractile force.

Contains Patented CreaTate? (Tricreatine Orotate ) US Patent No. 6,838,562 B

Boosts muscle phosphocreatine more effectively by providing creatine as well as Orotic Acid which increases muscle Uridine levels. Elevation of intramuscular Uridine levels increase muscle phosphocreatine and creatine levels 38% and 3%, respectively.

The only form of creatine that can boost muscle carnosine concentrations.
Great for sprinting.
Stacks well with BODYOCTANE?

The KING of CREATINES! ?

Aonuma, S., Hama, T., Tamaki, N., Okumura, H. (1969) Orotate as a beta-alanine donor for anserine and carnosine biosynthesis, and effects of actinomycin D and azauracil on their pathway. J.Biochem (Tokyo). 66 (2): 123-32.

Febbraio, M.A., Dancey, J. (1999) Skeletal muscle energy metabolism during prolonged, fatiguing exercise. J.Appl.Physiol. 87(6):2341-7.

Greenhaff PL, Casey A, Short AH, Harris R, Soderlund K, Hultman E. (1993) Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man. Clin.Sci. (Lond). 84: 565-71.

Rosenfeldt FL, Richards SM, Lin Z, Pepe S, Conyers RAJ. (1998) Mechanism of cardioprotective effect of orotic acid. Cardio.Drug.Ther. 12: 159-170.

Fausto N. (1972) The conversion of orotic acid into uridine 5-monophosphate b y isolated perfused normal and regenerating rat livers. Biochem.J. 129: 811-820.

Kypson J, Hait G, Mathew R. (1978) Effects of uridine on the performance and the metabolism of oxygenated and hypoxic rabbit hearts. J Mol Cell Cardiol. 10: 545-565.

Kreider RB, Melton C, Greenwood M, Rasmussen C, Lundberg J, Earnest C, Almada A. (2003) Effects of oral D-ribose supplementation on anaerobic capacity and selected metabolic markers in healthy males. Int.J.Sport.Nutr.Exerc.Metab. 13: 76-86.